Unsafe updates don't seem to properly trigger alarmed states in duplicants. When the game runs fast enough to cause heavy frameskip, duplicants will routinely make messes (usually right after waking up), trigger suffocation alerts in areas with lots of oxygen, and sometimes even begin starving.
This stops when the game speed is lowered.
1. Slow the computer down (background processes, huge colony full of pathing dupes etc.) 2. Set game speed high enough to cause heavy frameskip (~5 fps) 3. Wait