Just launched the game today and encountered an issue shown in the link below:
No matter where I move the pointer, it always moves up. The issue does not occur when ONI is closed, although it lingers a bit when Steam is slowly closing the game.
Unplugging/replugging the mouse and removing all mods and save files didn't help. The mouse works fine when playing other games. Launching the game by running OxygenNotIncluded.exe results in an "Another instance is already running" error even though the game does not appear in Windows Task Manager.
Just launch Oxygen Not Included.