I'm experiencing severe performance issues whenever I create or destroy a liquid pipe in this save, presumably from recalculating liquid flow or something similar. Forgive the poor pipe layout, but I deleted every pipe in my base and tried laying them out differently to see if it helped.
Originally I had pipes flowing in a straight line through several inputs/output (ie, a horizontal line through the hydroponics tiles). I tried changing this so that every liquid input/output had its own unique feed from a master pipe, but if anything this made it worse. The farm tiles in particular are when this started to become unplayable.
Performance was fine after I deleted all the pipes, and gradually got worse as I placed them back down again.
Windows 10, GTX 1070, i7 7700K.
Load save, add or remove some pipes to the network.