Worth mentioning that this is the first time I've tried using the liquid storage containers, which could be related. I'm going to try to replace them with traditional tanks and pumps and see if it helps.
I'm experiencing severe performance issues whenever I create or destroy a liquid pipe in this save, presumably from recalculating liquid flow or something similar. Forgive the poor pipe layout, but I deleted every pipe in my base and tried laying them out differently to see if it helped. Originally I had pipes flowing in a straight line through several inputs/output (ie, a horizontal line through the hydroponics tiles). I tried changing this so that every liquid input/output had its own unique feed from a master pipe, but if anything this made it worse. The farm tiles in particular are when this started to become unplayable. Performance was fine after I deleted all the pipes, and gradually got worse as I placed them back down again. Windows 10, GTX 1070, i7 7700K. The Cool Dump Cycle 168.sav