I created three job schedules for my dupes at the start of the game to accommodate my end game dupe load. I saved and quit the game, when I restarted the game, the schedule I had created (schedule 2) was gone. I didn't think anything about it until I recreated it this morning. Again, I shut down the game and restarted this afternoon. The empty schedule is gone again.
Steps to Reproduce
Create new job schedule. Don't place a dupe in the schedule. Save, shut down the game. Restart game. Load from last save.
This issue has not been confirmed by a developer yet.