Crash to Desktop on Save Game

There's nothing in your save game.

I never had a crash to desktop issue for the entire time I play ONI.

I'm very sure your problem is driver related issue.

When the developer team had done a great job at the core component of the game itself but your hardware driver is faulty;

There's nothing to fix with the game itself.

You will need to manually update your computer drivers.

This website will help you:

https://www.iobit.com/en/driver-booster.php

I had all my hardware drivers updated since my first install of Windows 10 (64-bit) and I had never experience any single CTD with ONI.

I will say the developer team had done a great job.

Everything went smoothly for me.

Oxygen Not Included 2019.08.22 - 11.30.33.04.mp4