Can't play the game at all

From your log, i would suggest to disable any antivirus for testing. (they cause known problems)

If this helps, check if you can make an exception for the folders used by the game (see below)

If this wont help, uninstall and remove ALL files from Oxygen not Included.

They are located in your Steam install folder, c:\user/appdata/local/klei and c:\user/appdata/locallow/klei. Then reinstall via steam.

 

It worked. thanks

Changed Status to Closed