Sometimes, if I'm pressing a direction when the game autosaves, it will get stuck inputting that direction. I've only noticed it in ruins/houses, not outdoors. And for what it's worth, I use the keyboard and mouse exclusively, with the default mapping. WASD for the directions. No controllers. No mods.
For example, one time, in the ruins, I was walking up when the game autosaved, and after it finished autosaving, Wilson wouldn't stop walking up no matter what. And another time, just now, I was walking left in my house when it autosaved, and Wilson wouldn't stop walking left. Both times, when I went to the menu to save quit, the game acted like I was still inputting the direction as well, cycling rapidly through the buttons. I had to mouse over and click the buttons to make sure the right one got selected. Even on the main menu, it was cycling rapidly through the buttons as if I were holding down a directional key. Save/quitting and closing out of the game completely, then booting it up again, fixed it.
It only happens rarely, and the save/quit/close/restart fixes it. But I figured I'd post it here, since now it's happened to me more than once.
Sometimes when holding a direction when the game autosaves, it will get stuck inputting that direction. Only rarely, though, apparently.