Something about the (OVERKILL on CRIT passive) for the TOADSTOMPER is massively over-tuned, or bugged.
In this run, it was multiplicativity increasing with every proc (as near as I could tell) - sorry I can't provide much more clear information.
The run before this I picked up the new WALLET power (+dmg%, based on current teffra) and hit a new PB of like 1.5 million, which I thought was weird since usually I get around 400k dmg in a run with 650k being my old PB. I then tweaked my gear a bit and ran again, this time NOT getting the WALLET - but refined my playstyle more, focusing on getting the procs from TOADSTOMPER and got like 1 billion damage done?? xD
Powers are in the attached picture, other gear was FLORACRANE, TORCHFLY and the new BONEJAW JAWBELT.
TOADSTOMPER was level 12, GEMMED as with CRIT DMG-y, PHASING-y and CONCENTRATED-y
Use the specified build, focus playstyle on stacking the TOADSTOMPER passive. Some of the random powers acquired in this particular run, might be responsible - hard to say.

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