So I had built a manual generator, and when a dupe went to run on it the game crashed with the "An Error Occurred Please Restart Game." message popping up.
It appears to be related to in the output log it does appear to be related to the manual generator:
[14:04:20.763]  [WARNING] FMODUnity.EventNotFoundException: FMOD Studio event not found 'event:/Buildings/BuildCategories/03Power/ManualGenerator/ManualGenerator_loop'
at FMODUnity.RuntimeManager.CreateInstance (System.String path) [0x00015] in <56ab4121dc004a8781287eb47d941d92>:0
at KFMOD.CreateInstance (System.String path) [0x00013] in <56ab4121dc004a8781287eb47d941d92>:0
Steps to Reproduce
I built a manual generator, put it on yellow alert, and then as soon as a dupe started using it the game bugged out.
This issue has not been confirmed by a developer yet.