As subject - the in-game crash screen is displayed, hitting report changes the button to "Please wait", ONI process consumes ~100% CPU (about 1 core), but seemingly nothing's happening. Waited 15 minutes, no change.
GPU: Intel Iris (Device ID: 0x0a2e Revision ID: 0x0009)
The game did work when I tried it last time (about a year ago), on macOS 10.12 on the same machine.
BTW, your instructions here are incorrect (out of date, I guess?). Save files are under ~/Library/Application Support//unity.Klei.Oxygen Not Included
Steps to Reproduce
Start a new game
This issue has not been confirmed by a developer yet.