Instant crash on load - Thermal Upgrade

One thing I did to combat it was to go back to the previous cycle, cancel just about everything, and just have my duplicates do something else for a while. Sometimes it works for me.

I had the same thing happen.

Deleting the last auto-save file, which in my case was empty, fixed it for me.

On Windows 10 you can find the files in the user documents folder:

C:\Users\[YOUR USERNAME]\Documents\Klei\OxyfwnNotIncluded\save_files\auto_save