I can't open the game

I had the same issue

UPDATE: After some searching I found this to work (I think this fix need to be pinned it was not easy to find). :

• Right-click ONI -> Properties -> Local Files -> Browse local files .... go into the OxygenNotIncluded_Data folder and delete StreamingAssets, then Properties -> Local Files -> Verify Integrity of Game Files

Please provide more information, I think I have the same issue but cant be sure because of this. 

When I first started playing the pre-alpha test I was able to load into main menu and load further into play games, since a patch a couple of days ago, it loads only until the main menu (I think) IO hear the main menu audio but all i am faced with is a " error crash dialog box" screen print attached. 

I have tried:

Delete Mods folder

Delete User config file )cant remember file name)

Verify files integrity

Edited December 12, 2020 by NioXin

Error in MainMenu.MainMenu.OnSpawn 
System.IO.DirectoryNotFoundException: Could not find a part of the path "C:\Users\Wes\Documents\Klei\OxygenNotIncluded\save_files/Careful  (BACKUP).sav" or "C:\Users\Wes\Documents\Klei\OxygenNotIncluded\cloud_save_files/76561198084819301\Careful \Careful  (BACKUP).sav"
  at LoadScreen.MigrateFile (System.String source, System.String dest, System.Boolean ignoreMissing) [0x0011e] in <1c58b1f98f5849baa9083bfd5185b144>:0 
  at LoadScreen.CheckCloudLocalOverlap () [0x001b6] in <1c58b1f98f5849baa9083bfd5185b144>:0 
  at LoadScreen.RefreshColonyList () [0x00013] in <1c58b1f98f5849baa9083bfd5185b144>:0 
  at LoadScreen.OnActivate () [0x00017] in <1c58b1f98f5849baa9083bfd5185b144>:0 
  at KScreen.Activate () [0x00017] in <f30d3c85d1f64155aa0dc6c7adb0d1eb>:0 
  at LoadScreen.ShowMigrationIfNecessary (System.Boolean fromMainMenu) [0x00046] in <1c58b1f98f5849baa9083bfd5185b144>:0 
  at MainMenu.OnSpawn () [0x0002d] in <1c58b1f98f5849baa9083bfd5185b144>:0 
  at KMonoBehaviour.Spawn () [0x0005d] in <f30d3c85d1f64155aa0dc6c7adb0d1eb>:0 

  at UnityEngine.Debug.LogError (System.Object message, UnityEngine.Object context) [0x00000] in <b8388ffefd6046f8a7b4080349da72eb>:0 
  at Debug.LogError (System.Object obj, UnityEngine.Object context) [0x00000] in <f30d3c85d1f64155aa0dc6c7adb0d1eb>:0 
  at DebugUtil.LogErrorArgs (UnityEngine.Object context, System.Object[] objs) [0x00000] in <f30d3c85d1f64155aa0dc6c7adb0d1eb>:0 
  at DebugUtil.LogException (UnityEngine.Object context, System.String errorMessage, System.Exception e) [0x00000] in <f30d3c85d1f64155aa0dc6c7adb0d1eb>:0 
  at KMonoBehaviour.Spawn () [0x00000] in <f30d3c85d1f64155aa0dc6c7adb0d1eb>:0 
  at KMonoBehaviour.Start () [0x00000] in <f30d3c85d1f64155aa0dc6c7adb0d1eb>:0