Riding the beefalo and long pressing the spacebar to pick up items on the ground sometimes will be failed when Lag Compensation ON. And you have to use click and short press to pick up numbers of items around you. Seems that the distance between the character and items has some conflicts.
The video is shown that the first time Picking was successful, but the second time the character showed abnormal 'convulsions'.
PS: World Settings: Master+Caves, Lag Compensation ON, Long-press on the spacebar