Great stories and builds here!
Myself, I've made it to cycle 60 (with 5 dupes) after about 12 tries.
I've researched everything, so now everything's at my disposal to try and keep this base running.
These are the balance issues I ran into:
Bio Distiller doesn't produce enough Algae to make it worth the trouble. I thought "now, I'll be able to really keep my air clean!" Not even enough to keep two Algae Deoxydizer's running. Also, what it does produce is just deposited on the floor, making the atmosphere toxic - something else to try and keep clean.
Water Purifier doesn't produce enough clean water to make it worth the trouble in my experience. You'd have to have several of these running - if you had the time and contaminated water available.
Air Scrubber doesn't produce enough clean air to make it worth the trouble. It also sits there most of the time with "empty pipe" doing nothing and no reason why.
By the end it was non-stop puking, contaminating everything, with no oxygen left, so that's where I laid it to rest.
Well, off to my next build!