Things I've tried so far:
Updating Nvidea drivers
Updating Windows 10
Verified file integrity through steam as well as reinstalling to a different drive
Deleting kplayerprefs.yaml, and all other files in the ~/Documents/Klei/OxygenNotIncluded folder
Running in Windows 8 compatibility mode
Things to note:
I have no security or antivirus software. Windows ransomware protection is disabled and I don't have any controlled folders.
More error messages pile up in the log the longer i leave the game frozen:
[20:45:18.809] [1] [INFO] -- GAME --
[20:45:18.914] [1] [WARNING] True Timelapse.OnNewDay but worldsToScreenshot is not empty
[20:45:19.307] [1] [INFO] Checking which steam branch we're on. Got: []
[20:45:20.529] [1] [INFO] Screen resolution updated, saving values to prefs: 2560x1440 @ 144, fullscreen: True
[20:45:37.364] [1] [WARNING] Insufficient keys to cover root plan menu Max of 14 keys supported but TUNING.BUILDINGS.PLANORDER has 15
[20:45:43.381] [1] [WARNING] missing 'ui' anim in 'artifacts_kanim (KAnimFile)'
[20:45:46.062] [1] [INFO] WattsonMessage OnActivate
[20:45:53.559] [1] [INFO] Saved to [C:\Users\samwi\Documents\Klei\OxygenNotIncluded\cloud_save_files/76561198004348813\Dystopia\Dystopia.sav]
[20:45:54.088] [1] [INFO] Saving screenshot to C:\Users\samwi\Documents\Klei\OxygenNotIncluded\cloud_save_files/76561198004348813\Dystopia\Dystopia.png
[20:45:54.394] [1] [INFO] Saving screenshot to C:\Users\samwi\Documents\Klei\OxygenNotIncluded\RetiredColonies\Dystopia\00000\Halcyial
d3d11: failed to create staging 2D texture w=636 h=404 d3dfmt=28 [887a0005]
d3d11: failed to create staging 2D texture w=96 h=64 d3dfmt=65 [887a0005]
d3d11: failed to create staging 2D texture w=96 h=64 d3dfmt=65 [887a0005]
d3d11: failed to create staging 2D texture w=636 h=404 d3dfmt=16 [887a0005]
d3d11: failed to create staging 2D texture w=96 h=64 d3dfmt=28 [887a0005]
d3d11: failed to create staging 2D texture w=96 h=64 d3dfmt=28 [887a0005]
d3d11: failed to create staging 2D texture w=636 h=404 d3dfmt=28 [887a0005]
d3d11: failed to create staging 2D texture w=636 h=404 d3dfmt=61 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=192 h=192 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=192 h=192 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=192 h=192 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create staging 2D texture w=32 h=32 d3dfmt=2 [887a0005]
d3d11: failed to create buffer (target 0x5 mode 1 size 1824) [0x887A0005]
d3d11: failed to create buffer (target 0x2 mode 1 size 228) [0x887A0005]
Googling these errors seems to suggest i'm running out of VRAM, but my graphics card (gtx 1080) should be beefy enough to handle the game fine. Any suggestions on what to try next?