I've got a few questions:
1) This bug is marked as Preview Branch, does that mean you are running 'Griftlands Experimental' from the Epic store?
2) Could you send us the log that should be in [Windows Documents]/Klei/Griftlands_testing/[large number]/log.txt (change Griftlands_testing to just Griftlands if you are running 'Griftlands' from the Epic Store) ? Please send it to email@example.com and say it's for Nick.
3) What folder is the game installed in?
4) Are you running with the latest nVidia drivers?
Thanks, and I'll do my best to figure out what is going on here.