Its after midnight, my real PC died this afternoon (fried by lightning thru my cable modem connection), and I am using a tiny keyboard on a PC that can't game that I borrowed from a friend.
I can not game, so I must scream.
Where to begin? This isn't base porn; its more like a base snuff-film.
Power...you shouldn't be overloading anything, you have too much load on your grid. You need to break your one "big" grid up into separate grids that won't exceed a 1K load. But first, you need to simplify your power consumers:
You don't need 3 micro mushers. Only 1. And stop making mush bars. Never make mush bars unless you are starving in-between plant or critter harvests. And if that happens, plant\ranch more to NEVER eat mush bars. I haven't made a mush bar since my 1st base. Go mealwood and eat it raw early game.
You don't need so many terrariums and oxygen diffusers. Go with one or the other. Maybe go with just terrariums until you get power under control, but remember that they require Dupes maintaining them and your terrarium farm at the top of the base is as far from water as possible.
You don't need 3 research stations. At most 1 research station and one super computer so that at most you only have 2 dupes doing research at any given moment.
I'm guessing you have some farty dupes based on the natural gas I see. Stay away from farty dupes; that is a neg trait for experienced players who want a challenge.
You don't seem to be aware of the room overlay or the bonuses to morale a room gives the dupes (i think you just have the one bedroom in the bottom that may give a bonus and the bathroom). Click on the room overlay and look at the descriptions to see what you need to get the bonuses.
Howto avoid germs will take too long to type on this keyboard...do a search on how to avoid and handle them
This is mostly for Food Poisoning prevention: I consider dupes disinfecting everything as a waste of time. I set my disinfect to 1 germ (I know this triggers the dupes to disinfect with the slightest sign of germs) but I disable disinfect on most things that get germy normally (bathroom stuff, compost, deoderizers). What this does is prevents dupes disinfecting everything and just doing the animation when normal stuff gets dirty. Stuff that when it gets dirty, you know a dupe is spreading it around. That is when I pause and check my dupes for germs to see who is spreading them around. Then I direct them to wash their hands and I can continue from this interruption.
On your next base, try to have the stuff you need near the stuff that needs it so your dupes run around less and get more accomplished faster.
There is so much more to say, but its late, others can contribute minus the snark, and you can maybe watch some youtubers like Grind This Game to learn more.