I'm playing Hamlet and encountered a really annoying bug several times. I play with a 360 controller, and when Gnats come around my head, I can no longer enter buildings, and it's very hard to pick up items. This is caused by the player selected item being gnats no matter what since it's the closest item, thus making it impossible to interact with item a bit farther such as building, which have a collision box.
It's surprising that this bug made it past beta, since it basically makes you useless until the evening when gnats go away.
While I'm at it, there's also a controller bug in DST, where we can't throw things. This makes it impossible to throw a boat kit, so it's impossible to sail in the return of them beta when playing with a controller.