Ammended the original post with additional system details.
Save file attached, I read on the Ranching upgrade notes that performance may be degraded due to additionally tracing/logging but on Cycle 56, my game is nearly unplayable. It's lagging and stuttering beyond a playable state. System Specs: i7-3770k 32GB DDR4 SSD HDD Nvidia GeForce GTX 980 Ti Resource Monitor shows low levels of CPU/Memory/Network/Disk usage. I tried toggling off Metrics data but I still see network requests coming from ONI, could be steam related. The jitter dissipates on "Play" mode, it's mostly noticeable on FFW. The save only has 10 duplicants on Day 56, I've played to 350+ with less impact to performance.