This is less a bug report but more a pointer toward a solution:
When you load a game the simulation is paused, this leads to the duplicants not following commands, the resources seem to be gone (as the simulation needs to run a bit to update the numbers) and one is unable to build (dito).
The solution to all this is what I have posted in don't know how many bug reports so far and is simple:
The game is paused, press space to continue...
Steps to Reproduce
Load a save, don't know that it's only paused, open a new bug on the tracker.
This issue has not been confirmed by a developer yet.