Note: this applies to the Linux version as well.
Full story: I was playing the game when I read the announcement for the last update 399948. So I save the game, exit to desktop, restart ONI, Steam applies updates, I load the savefile. I immediately hear glitchy sound effects. I keep playing, after a while the game freezes. I'm unable to switch to desktop, run task manager etc. Power cycle the pc, relaunch game. Still sound problems, this time I can play for longer, but it the end, still freezes. Next boot, I try a local file integrity check on steam. All fine. Launch the game, almost immediate freeze.
I switch to Linux (Fedora 31 w Lutris). I've played in the past, the game works perfectly, just the mouse has a small annoying delay so I prefer to play on Windows. But I know it used to work, I could even copy savefiles back and forth between OSes. So Steam starts, it updates the game, game runs. Same glitchy sounds. And after a bit, it freezes. Frankly I haven't tried connecting via network on my Linux box, so I can't confirm is a solid system freeze or just the graphics. Now, this has to be related to the last patch. Anyway the behavior is exactly the same on Windows and Linux. I can't access the desktop, on Linux not even virtual consoles. I've tried many time, it always happens. Mouse and keyboard completely unresponsive. But, in some cases, I can still hear ONI music playing.
Anyway, I reboot Windows and watch some videos on YT (no sound problems, all is working fine) and call it a night.
This morning I try again. It freezes 5 minutes in the game. So not temperature related even. Then I disable all MODs and try again. Same effect. The attached logfile is from the unmodded session. Needless to say unfortunately the game is unplayable in this state.
Sound glitches are rather easy... All I have to do is drag a dig command on a large area. Or even, just zoom in on my hatches ranches, and do nothing. I hear metallic sounds, squeaks, and so on. Freezes are completely random. Most of the times happen within 5-10 minutes.