The game will just hard crash back to Desktop, or freeze completely (Windows loading cursor, message "App does not respond"). It seems that this happens more frequently the further the game progresses or the more stuff there is going in, they come in a package really. I'm around cycle 195 with 7 duplicants and a bunch of stuff to do and the game crashes after roughly 2-4 cycles. I started to really notice it around cycle 100-ish, when the crashes started to get more frequent, about every 15-20 cycles.
Steps to Reproduce
Load the savegame and try to play more than 4 cycles :-)
This issue has not been confirmed by a developer yet.