When I play at 5120x1440 there are a number of graphical oddities. For example, the graphics indicating build commands will be duplicated on the left side of the screen. They will pop in and out and move around as I scroll around the map. The text popups are also really huge. You can see examples of both in the screenshots below.
The aspect ratio for the tutorial videos is also incorrect -- the top and bottom of the video are cut off as the video scales to the horizontal width of the display.
Reducing the resolution to 2560x1440 is my current workaround.
Play the game at 5120x1440 resolution.