I'm sorry this isn't a specific 'bug', but more like a general thing I noticed. Basically, before the optimizations you guys made in the last couple updates, the game used to barely run - couldn't have more than 8 dupes and once infrastructure got too big, I'd be reduced to the horrible 20fps or something. Then you guys did the last update, OC and tubular were fantastic - I was running 24 dupes to 500-600 cycles and still in the high 40s fps. Now, I'm back to running 10 dupes at cycle 100 and I'm dipping into the low 30s fps again.
Honestly, it makes the game completely unplayable. I have barely done anything at this point in the game, just setup my inner base and some water supply, and its already running so much slower that I don't want to keep playing. The hangs and microstutters constantly kill the enjoyment.
So I'm not sure if it's the way the new priority system is slowing everything down (bring back the old priority system!) or if there are optimizations that need to be performed again, but right now it's basically unplayable I'm not running a slouch computer either, it's an i7-3930K OC'd to like 4+GHz with 16gb of ram.
Run the game, build big base, watch game run super slow