*edited to correct misinformation on my part*
I know there is a bug that when loading a save your food can disappear. However, this happened to me in real time. I was playing on Cycle 10 going to Cycle 11 and as soon as it ticked over I got the alert that I had a food shortage. The food was less than 2 days old so it didn't spoil, it just flat out disappeared.
I'm not sure what caused it, it happened as I was going from cycle 10 to cycle 11. I had 4 duplicants and was producing liceloaf when they went to sleep.