When an airflow tile has a gas in the same tile and the game is saved and then loaded, the gas is (before unpausing the simulation) forcibly pushed out of the tiles - this can result in some incredibly strange gas compression/moving, and can potentially even be used for exploitative purposes. In my specific case, it's breaking a carefully regulated airflow system.
Using mesh tiles does not cause this issue, so I assume it's related to the way it blocks liquids from entering the tile.
Steps to Reproduce
-Build an enclosed room -Cover the entire room except one tile in airflow tiles -Fill it with gas and note how much gas is in each tile -Save, then load the game -Before unpausing, examine the amounts of gas in each tile, at this point there should be a vacuum behind each airflow tile instead of the gas that should have been there (which is the bug)
This issue has not been confirmed by a developer yet.