I just started a new world, and started building my base, by making a fire pit and a Science Machine. I decided to make some traps, so I went looking for the materials I would need, and when I came back, my base was gone. I've seen a thread where someone was having a similar issue, but in the regular Don't Starve, PS4 version.
This was in the PC\Windows version by the way.
Steps to Reproduce
I made a base with a fire pit and a Science machine in the Deciduous Forest while I was playing as WX-78 on Social Mode. I walked away from it at the begging of the next day, and went a fairly long distance. I collected some cut grass and twigs and came back almost at night, to see that the base was gone.
This issue has not been confirmed by a developer yet.